Observe Carefully (1)pentobarbital will lessen the extent or impact of glecaprevir/pibrentasvir by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will minimize the extent or effect of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.pentobarbital will reduce the extent or outcome o